|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
Recognition of H-2Kb mutant target cells by Kb-specific alloreactive memory T cellsстатья Тезисы
Дата последнего поиска статьи во внешних источниках: 14 октября 2021 г.
- Авторы: Kazansky D., Chemysheva A., Sernova N., Anfalova T., Khromykh L., Pobezinsky L., Agafonova E.
- Журнал: FASEB Journal
- Том: 11
- Номер: 3
- Год издания: 1997
- Издательство: Federation of American Societies for Experimental Biology
- Местоположение издательства: United States
- Первая страница: A310
- Аннотация: Allospecific immune responses against the MHC of another individual are remarkably strong, due to a high number of responding T cell clones As it was shown earlier, many of them display biased TCR Vβ usage. To investigate whether this biased TCR gene usage could be due to restricted structural diversity of epitopes responsible for allorecognition, we have studied the effect of mutations in H-2Kb molecule on recognition by Kb-specific memory T cells generated from R101 (KdIdDb) mice by immunisation with EL4 (KbDb) cells This immunisation resulted in formation of Kb-specific memory cells which were mostly CD8+ cells and could be detected by the MLC responses to heat-treated (45 degrees, 30′) stimulator cells The allogeneic memory response to B6C-H-2 bml (Kbm1IbDb) stimulator cells was comparable with response to C57BL/6 (KbIbDb) and B6.C-H-2 bm12 (KbAβbm12Db) cells. The responses to B6.C-H-2 bm3 (Kbm3IbDb) and B6.C-H-2 bm4 (Kbm4IbDb) cells were significantly reduced. The data suggest that point mutations in the α-helices of Kb-molecule can affect the recognition by the TCRs of whole population of alloreactive memory cells, indicating on existence of immunodominant epitopes responsible for allogeneic recognition of the MHC class I molecules.
- Добавил в систему: Казанский Дмитрий Борисович