Formation of spatial memory in rats with ischemic injury of prefrontal areas of the cortex; Effects of a sinthetic analogue of ACTH(4-7)статья
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:It was shown, that photochemically induced thrombosis of blood vessels in prefrontal areas of the cortex lead to the formation of well-defined infarct zone. Bilateral prefrontal cortex injury Impair acquisition of the Morris water-maze on postoperative days 20-24. Chronic treatment of brain-injuried rats with peptide semax, a synthetic analogue of ACTH(4-7), at a dose of 250 mu g/kg (intranasal, once a day) during six days after photothrombosis resulted in restoration of spatial learning ability. The observed long-lasting antiamnesic effects of the semax are probably caused by its strong neuroprotective action, and ability to induce synthesis of nerotrophic factors.