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Organoids: a novel modality in disease modelingстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 29 сентября 2021 г.
- Авторы: Heydari Zahra, Moeinvaziri Farideh, Agarwal Tarun, Pooyan Paria, Shpichka Anastasia, Maiti Tapas K., Timashev Peter, Baharvand Hossein, Vosough Massoud
- Журнал: Bio-Design and Manufacturing
- Том: 4
- Номер: 4
- Год издания: 2021
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- Первая страница: 689
- Последняя страница: 716
- DOI: 10.1007/s42242-021-00150-7
- Аннотация: Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more accurately. Recent advances in the improvement of protocols have resulted in establishing three-dimensional (3D) organ-like architectures called ‘organoids’ that can display the characteristics of their corresponding real organs, including morphological features, functional activities, and personalized responses to specific pathogens. We discuss different organoid-based 3D models herein, which are classified based on their original germinal layer. Studies of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating practical knowledge along with preclinical studies, including drug screening, toxicology, and molecular pathophysiology of diseases. This paper also outlines the key challenges, advantages, and prospects of current organoid systems.
- Добавил в систему: Тимашев Петр Сергеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
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| 1. | Organoids__a_novel_modality_in_disease_modeling___Enhanced_… | Organoids__a_novel_modality_in_disease_modeling___Enhanced_… | 16,4 МБ | 28 сентября 2021 [TPS_SU] |