EPIGENETIC REGULATION OF BRCA1 EXPRESSION AND ITS ROLE IN BREAST CANCER STEM CELL DEVELOPMENT

Shestakova, E.A.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.

Автор: Shestakova E.A.
Журнал: Turkish Journal of Biology
Том: 40
Номер: 5
Год издания: 2016
Издательство: Scientific and Technical research Council of Turkey - TUBITAK/Turkiye Bilimsel ve Teknik Arastirma Kurumu
Местоположение издательства: Turkey
Первая страница: 981
Последняя страница: 989
DOI: 10.3906/biy-1507-145
Аннотация: The tumor suppressor breast cancer 1, early onset (BRCA1) plays an important role in maintaining the genome integrity,actively participating in DNA repair via homologous recombination. The level of functional final BRCA1 protein is precisely regulatedin cells. Epigenetic regulation of BRCA1 gene expression is one of the most important mechanisms for BRCA1 level fine-tuning. In thisreview the main epigenetic mechanisms of BRCA1 expression regulation are presented, including DNA methylation, histone covalentmodifications, and regulation with transcription factors. Another important function of BRCA1 emerging in recent years is its role inthe regulation of breast cancer stem cell development. Moreover, based on its multiple functions, BRCA1 is also arising as a powerfulbiomarker. In particular, it could be used as a prognostic marker of the course of the disease and as a predictive marker of the efficiencyof platinum-based chemotherapy.Key words: Breast cancer 1, early onset, (BRCA1) epigenetic regulation, histone, DNA modifications, breast cancer stem cells
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