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Improved cytocompatibility and antibacterial properties of zinc-substituted brushite bone cement based on β-tricalcium phosphateстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
- Авторы: Fadeeva Inna V., Goldberg Margarita A., Preobrazhensky Ilya I., Mamin Georgy V., Davidova Galina A., Agafonova Nadezhda V., Fosca Marco, Russo Fabrizio, Barinov Sergey M., Cavalu Simona, Rau Julietta V.
- Журнал: Journal of materials science. Materials in medicine
- Том: 32
- Номер: 9
- Год издания: 2021
- Издательство: SPRINGER
- Местоположение издательства: VAN GODEWIJCKSTRAAT 30, DORDRECHT, NETHERLANDS, 3311GZ
- Номер статьи: 99
- DOI: 10.1007/s10856-021-06575-x
- Аннотация: For bone replacement materials, osteoconductive, osteoinductive, and osteogenic properties are desired. The bacterial resistanceand the need for new antibacterial strategies stand among the most challenging tasks of the modern medicine. In this work,brushite cements based on powders of Zinc (Zn) (1.4 wt%) substituted tricalcium phosphate (β-TCP) and non-substituted β-TCPwere prepared and investigated. Their initial and final phase composition, time of setting, morphology, pH evolution, andcompressive strength are reported. After soaking for 60 days in physiological solution, the cements transformed into a mixture ofbrushite and hydroxyapatite. Antibacterial activity of the cements against Enterococcus faecium, Escherichia coli, andPseudomonas aeruginosa bacteria strains was attested. The absence of cytotoxicity of cements was proved for murine fibroblastNCTC L929 cells. Moreover, the cell viability on the β-TCP cement containing Zn2+ ions was 10% higher compared to theβ-TCP cement without zinc. The developed cements are perspective for applications in orthopedics and traumatology.
- Добавил в систему: Преображенский Илья Иванович