Proteolysis and isopeptidolysis during thrombolysisтезисы доклада

Работа с тезисами доклада


[1] Proteolysis and isopeptidolysis during thrombolysis / S. Kalabushev, A. Kurdyumov, V. Manuvera et al. // 24- th Biennial International Congress on Thrombosis, Стамбул, Турция. 4-7 мая 2016. — Стамбул, 2016. Intravenous administration of recombinant Destabilase is followed by thrombi slow (> 24h) dissolution. Degree of thrombolysis stimulated by Destabilase was higher than by Streptokinase, clinical thrombolytic agent. In similar setting, degree of lysis was higher for arterial vs. venous thrombi. Degradation of isopeptide bonds by Destabilase was a crucial parameter for stabilized fibrin lysis. It results in slow spontaneous transition of the old thrombi from solid to soluble state. Thus, Destabilase is able to perform thrombolysis independent of proteolysis.

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