Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort study

Osmanov, I.M.; Spiridonova, E.; Bobkova, P.; Gamirova, A.; Shikhaleva, A.; Andreeva, M.; Blyuss, O.; El-Taravi, Y.; DunnGalvin, A.; Comberiati, P.; Peroni, D.G.; Apfelbacher, C.; Genuneit, J.; Mazankova, L.; Miroshina, A.; Chistyakova, E.; Samitova, E.; Borzakova, S.; Bondarenko, E.; Korsunskiy, A.A.; Konova, I.; Hanson, S.W.; Carson, G.; Sigfrid, L.; Scott, J.T.; Greenhawt, M.; Whittaker, E.A.; Garralda, E.; Swann, O.; Buonsenso, D.; Nicholls, D.E.; Simpson, F.; Jones, C.; Semple, M.G.; Warner, J.O.; Vos, T.; Olliaro, P.; Sechenov StopCOVID Research Team, D.M.

Авторы: Osmanov Ismail M., Spiridonova Ekaterina, Bobkova Polina, Gamirova Aysylu, Shikhaleva Anastasia, Andreeva Margarita, Blyuss Oleg, El-Taravi Yasmin, DunnGalvin Audrey, Comberiati Pasquale, Peroni Diego G., Apfelbacher Christian, Genuneit Jon, Mazankova Lyudmila, Miroshina Alexandra, Chistyakova Evgeniya, Samitova Elmira, Borzakova Svetlana, Bondarenko Elena, Korsunskiy Anatoliy A., Konova Irina, Hanson Sarah Wulf, Carson Gail, Sigfrid Louise, Scott Janet T., Greenhawt Matthew, Whittaker Elizabeth A., Garralda Elena, Swann Olivia, Buonsenso Danilo, Nicholls Dasha E., Simpson Frances, Jones Christina, Semple Malcolm G., Warner John O., Vos Theo, Olliaro Piero, Sechenov StopCOVID Research Team Daniel Munblit
Журнал: European Respiratory Journal
Год издания: 2021
Издательство: European Respiratory Society
Местоположение издательства: Switzerland
DOI: 10.1183/13993003.01341-2021
Аннотация: Background The long-term sequelae of coronavirus disease 2019 (Covid-19) in children remain poorly characterised. This study aimed to assess long-term outcomes in children previously hospitalised with Covid-19 and associated risk factors.Methods This is a prospective cohort study of children (≤18 years old) admitted with confirmed Covid-19. Children admitted to the hospital between April 2, 2020 and August 26, 2020, were included. Telephone interview using the International Severe Acute Respiratory and emerging Infection Consortium (ISARIC) Covid-19 Health and Wellbeing paediatric follow-up survey. Persistent symptoms (>5 months) were further categorised by system(s) involved.Findings 518 of 853 (61%) of eligible children were available for the follow-up assessment and included in the study. Median age was 10.4 years (IQR, 3–15.2) and 270 (52.1%) were girls; median follow-up since hospital discharge was 256 (223–271) days. At the time of the follow-up interview 126 (24.3%) participants reported persistent symptoms among which fatigue (53, 10.7%), sleep disturbance (36, 6.9%,) and sensory problems (29, 5.6%) were the most common. Multiple symptoms were experienced by 44 (8.4%) participants. Risk factors for persistent symptoms were: older age “6–11 years” (odds ratio 2.74 (95% confidence interval 1.37 to 5.75) and “12–18 years” (2.68, 1.41 to 5.4); and a history of allergic diseases (1.67, 1.04 to 2.67).Interpretation A quarter of children experienced persistent symptoms months after hospitalization with acute covid-19 infection, with almost one in ten experiencing multi-system involvement. Older age and allergic diseases were associated with higher risk of persistent symptoms at follow-up.
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Risk factors for long covid in previously hospitalised children using the ISARIC Global follow-up protocol: A prospective cohort studyстатья