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Free fall landing and interval running have different effects on trabecular bone mass and microarchitecture, serum osteocalcin, biomechanical properties, SOST expression and on osteocyte related characteristicsстатья
- Авторы: Boudenot Arnaud, PALLU stephane, UZBEKOV Rustem, DOLLEANS Eric, Toumi Hechmi, LESPESSAILLES Eric
- Журнал: Applied Physiology, Nutrition and Metabolism
- Год издания: 2021
- Издательство: National Research Council Canada
- Местоположение издательства: Canada
- DOI: 10.1139/apnm-2020-0683
- Аннотация: The effects of treadmill interval training (IT) and free fall exercise were evaluated on bone parameters including osteocyte related characteristics. Thirty-eight 4-month-old male Wistar rats were randomly divided into a control group (C) and exercise groups: IT, 10 free fall impacts/day with a 10s (FF10) or 20s interval between drops (FF20), 5 days/week, for 9 weeks. We assessed: BMD, microarchitecture by µCT, mechanical strength by a three-point bending test, density and occupancy of the osteocyte lacunae by toluidine blue staining, osteocalcin and NTx systemic levels by ELISA, and bone tissue Sost mRNA expression by RT-PCR. NTx levels were significantly lower in exercise groups as compared to C. In exercise groups Sost mRNA expression was significantly lower than in C. Tb.N was significantly higher for IT and FF20 compared to C; Tb.Sp was significantly lower in FF10 compared to C. Both IT and FF20 were associated with higher tibial lacunar density as compared to FF10. Compared to FF10, IT fat mass was lower, while tibial osteocyte lacunae occupancy and systemic osteocalcin level were higher. All exercise modes were efficient in reducing bone resorption. Both IT and FF impact with appropriate recovery periods might be beneficial for bone health and osteocyte related characteristics. Novelty bullets: • Interval training is beneficial for bone mineral density • Exercises decreased both bone resorption and inhibition of bone formation (sost mRNA) • Longer interval recovery time favors osteocyte lacunae density.
- Добавил в систему: Узбеков Рустем Эдуардович