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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Calculation of Na+/Cl− Selectivity in Tight Junctions between Epithelial Cells by Methods of Nonlocal Electrostatics with Pole Models of Dielectric Function without an Overscreening Effectстатья
Дата последнего поиска статьи во внешних источниках: 1 апреля 2022 г.
- Авторы: Rubashkin A.A., Iserovich P.
- Журнал: Cell and Tissue Biology
- Том: 12
- Номер: 4
- Год издания: 2018
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 323
- Последняя страница: 330
- DOI: 10.1134/S1990519X18040089
- Аннотация: A mathematical model of Na+/Cl− selectivity in tight junctions (TJs) between epithelial cells was developed. It was demonstrated that Na+/Cl− selectivity in TJs depends on the total charge of amino-acid residues of claudin macromolecules within TJs, as well as on the ion-distribution coefficients between TJs and free solution. It was demonstrated that the obtained formulas predict a change of Na+/Cl− selectivity in TJs for Cl−/Na+ selectivity if the sign of the total charge of amino-acid residues in TJ changes. The calculated Na+/Cl− selectivity value for MDCK cells coincides with the experimental data of (Colegio et al., 2002). To calculate a change in ion-solvation energy during their transition to TJs, formulas for nonlocal electrostatics with one-, two-, and three-pole models of dielectric function without taking into account the overscreening effect were used.
- Добавил в систему: Рубашкин Андрей Александрович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Rubashkin-Iserovich2018_Article_CalculationOfNaClSelectivit… | 388,0 КБ | 1 июля 2021 [RubashkinAA] |