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Epidemiological and cytological profile of acute myeloid leukaemias: A proposed 126 college cases at the Batna anti cancer centerстатья
Дата последнего поиска статьи во внешних источниках: 27 октября 2021 г.
- Автор: Youcefi afaf et saidi mahdia
- Журнал: Journal of Leukemia and Lymphoma
- Том: 1
- Год издания: 2021
- Издательство: Zhonghua Yixeuehui Zazhishe/Chinese Medical Association Publishing House
- Местоположение издательства: China
- Первая страница: 2
- Аннотация: Abstract: Background: Acute myeloid leukemias are heterogeneous clonal hematologic malignancies caused by the transformation of a hematopoietic stem cell or an already committed progenitor to the myeloid lineage. The objective of this work is to describe the epidemiological and cytological characteristics of peripheral blood and marrow in 126 patients with AML at the Batna Anti-Cancer Center between 2016 and 2019Methods :The diagnostic criteria are based on the morphology of cells under the microscope, cytochemistry, clinical presentation, immunophenotyping of blasts by flow cytometry, cytogenetics and the search for certain molecular markers.Results: The age of the patients ranged from 15 to 88 years, Morphological examination of blood and marrow smears and myeloperoxidase reaction allowed AML to be classified according to the criteria of the FAB group: 1) 9.5 % of AML0; 2) 17.5% of AML1; 3) 11.1% of LAM2; 4) 13.5% of LAM3; 5) 15.1% LAM4; 6) 16.7% of LAM5; 7) 3.2% LAM6; 8) 0% of LAM7. And we have 12.7% of cases difficult to classify, and 0.8% of biphenotypic cases. Conclusions: Discrepancies in terms of percentages are noted between the subtypes M0,M1 andM2. These results must be supplemented by studies of cytogenetics and molecular biology
- Добавил в систему: youcefi afaf allouache