Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunity

Stovbun, S.V.; Kalinina, T.S.; Zlenko, D.V.; Kiselev, A.V.; Litvin, A.A.; Bukhvostov, A.A.; Usachev, S.V.; Kuznetsov, D.A.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 4 августа 2021 г.

Авторы: Stovbun Sergey V., Kalinina Tatiana S., Zlenko Dmitry V., Kiselev Aleksei V., Litvin Alexander A., Bukhvostov Alexander A., Usachev Sergey V., Kuznetsov Dmitry A.
Журнал: International Journal of Biological Macromolecules
Том: 182
Год издания: 2021
Издательство: Elsevier BV
Местоположение издательства: Netherlands
Первая страница: 743
Последняя страница: 749
DOI: 10.1016/j.ijbiomac.2021.03.135
Аннотация: The development of high-end targeted drugs and vaccines against modern pandemic infections, such as COVID-19, can take a too long time that lets the epidemic spin up and harms society. However, the countermeasures must be applied against the infection in this period until the targeted drugs became available. In this regard, the non-specific, broad-spectrum anti-viral means could be considered as a compromise allowing overcoming the period of trial. One way to enhance the ability to resist the infection is to activate the nonspecific immunity using a suitable driving-up agent, such as plant polysaccharides, particularly our drug Panavir isolated from the potato shoots. Earlier, we have shown the noticeable anti-viral and anti-bacterial activity of Panavir. Here we demonstrate the pro-inflammation activity of Panavir, which four-to-eight times intensified the ATP and MIF secretion by HL-60 cells. This effect was mediated by the active phagocytosis of the Panavir particles by the cells. We hypothesized the physiological basis of the Panavir proinflammatory activity is mediated by the indol-containing compounds (auxins) present in Panavir and acting as a plant analog of serotonin.
Добавил в систему: Зленко Дмитрий Владимирович

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

Интеллектуальная Система Тематического Исследования НАукометрических данных

Antiviral potential of plant polysaccharide nanoparticles actuating non-specific immunityстатья

Прикрепленные файлы