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Quantification of the interceptor action of caffeine on the in vitro biological effect of the anti-tumour agent topotecanстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 декабря 2016 г.
- Авторы: Evstigneev M.P., Mosunov A.A., Evstigneev V.P., Parkes H.G., Davies D.B.
- Журнал: European Biophysics Journal
- Том: 40
- Номер: 8
- Год издания: 2011
- Издательство: Springer Verlag
- Местоположение издательства: Germany
- Первая страница: 969
- Последняя страница: 980
- DOI: 10.1007/s00249-011-0712-5
- Аннотация: Using published in vitro data on the dependence of the percentage of apoptosis induced by the anti-cancer drug topotecan in a leukaemia cell line on the concentration of added caffeine, and a general model of competitive binding in a system containing two aromatic drugs and DNA, it has been shown to be possible to quantify the relative change in the biological effect just using a set of component concentrations and equilibrium constants of the complexation of the drugs. It is also proposed that a general model of competitive binding and parameterization of that model may potentially be applied to any system of DNA-targeting aromatic drugs under in vitro conditions. The main reasons underpinning the proposal are the general feature of the complexation of aromatic drugs with DNA and their interaction in physiological media via hetero-association. © 2011 European Biophysical Societies’ Association.
- Добавил в систему: Евстигнеев Максим Павлович