1H NMR study of the complexation of aromatic drugs with dimethylxanthine derivativesстатья
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Дата последнего поиска статьи во внешних источниках: 2 декабря 2016 г.
Авторы:
Hernandez Santiago A.A. ,
Gonzalez Flores M. ,
Rosas Castilla S.A. ,
Cervantes Tavera A.M. ,
Gutierrez Perez R. ,
Khomich V.V. ,
Ovchinnikov D.V. ,
Parkes H.G. ,
Evstigneev M.P.
Журнал:
Journal of Molecular Structure
Том:
1010
Год издания:
2012
Издательство:
Elsevier BV
Местоположение издательства:
Netherlands
Первая страница:
139
Последняя страница:
145
DOI:
10.1016/j.molstruc.2011.11.045
Аннотация:
With an aim of searching efficient interceptors of aromatic drugs, the self- and hetero-association of dimethylxanthine derivatives with different structures, selected according to Strategy 1 (variation of the position of methyl groups) and Strategy 2 (variation of the length of (CH 2) nCOOH group), with aromatic drug molecules: Ethidium Bromide, Proflavine and Daunomycin, were studied using 1H NMR spectroscopy. It was found that the association proceeds in a form of stacking-type complexation and its energetics is relatively independent on the structure of the dimethylxanthines. However, on average, the dimethylxanthines possess higher hetero-association constant and, hence, higher interceptor ability as compared to the trimethylxanthine, Caffeine, used during the past two decades as a typical interceptor molecule. © 2011 Elsevier B.V. All rights reserved.
Добавил в систему:
Евстигнеев Максим Павлович