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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Complexation of aromatic drugs with single-walled carbon nanotubesстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Buchelnikov A.S., Voronin D.P., Kostjukov V.V., Deryabina T.A., Khrapatiy S.V., Prylutskyy Y.I., Ritter U., Evstigneev M.P.
- Журнал: Journal of Nanoparticle Research
- Том: 16
- Номер: 7
- Год издания: 2014
- Издательство: Springer Nature
- Местоположение издательства: Switzerland
- DOI: 10.1007/s11051-014-2472-5
- Аннотация: We report a detailed study of the complexation of aromatic molecules and drugs with the surface of single-walled carbon nanotubes (SWCNTs, the diameter and the length ranges are 0.5-2 nm and 1-5 μm, respectively) in terms of equilibrium binding constants, K. It is found that the binding constants have magnitudes of the order of 104-105 M-1 and that there is some ligand specificity to the SWCNT surface depending on the structure of the aromatic molecule. The observed specificity is strongly governed by the curvature of the ligand chromophore and the type of side chains, resulting in the highest K for methylene blue which closely matches the curvature of the SWCNT surface. Stabilization of the drug-SWCNT complexes is found to be mainly due to intermolecular van der Waals forces and to a lesser extent by hydrophobic interactions. The approach suggested for determination of the binding parameters may be used as an alternative, or complementary, to standard Langmuir analysis. © 2014 Springer Science+Business Media.
- Добавил в систему: Евстигнеев Максим Павлович