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A covalently linked dyad based on zinc phthalocyanine and methylpheophorbide a: synthetic and physicochemical studyстатья
Статья опубликована в журнале из списка RSCI Web of Science
Статья опубликована в журнале из перечня ВАКСтатья опубликована в журнале из списка Web of Science и/или Scopus
- Авторы: Balashova Irina O., Tolbin Alexander Yu, Tarakanov Pavel A., Krot Alexei R., Fedorova Kseniya V., Sergeeva Irina A., Trashin Stanislav A., De Wael Karolien, Pushkarev Victor E., Koifman Mikhail O., Ponomarev Gelii V.
- Журнал: Макрогетероциклы
- Том: 14
- Номер: 1
- Год издания: 2021
- Издательство: Федеральное государственное бюджетное образовательное учреждение высшего образования "Ивановский государственный химико-технологический университет"
- Местоположение издательства: Иваново
- DOI: 10.6060/mhc210338p
- Аннотация: The first covalently linked conjugate of metal phthalocyaninate and chlorin e 6 derivativehas been obtained by transesterification of α-keto methyl ester in methylpheophorbide awith zinc(II) 2(2hydroxymethylbenzyloxy)-9(10),16(17),23(24)-tri-tert-butylphthalocyaninate under mild conditions. The dyad exhibits a panchromatic naturerevealing both the phthalocyanine and pheophorbide derived bands in the UV-Visabsorption spectrum. The 1 H NMR spectroscopy data combined with theoreticalcalculations indicate the presence of spatial intramolecular interactions between thephthalocyanine, pheophorbide and spacer fragments of the dyad allowing to forecast itsenhanced nonlinear optical properties, as well as the characteristic energy transfer fromthe excited pheophorbide subunit to the phthalocyanine core. Indeed, when excited inthe UV-Vis range, the conjugate shows red fluorescence with the spectral maximum at686 nm, which is close to the one of the initial zinc phthalocyaninate. Furthermore, thedyad effectively generates singlet oxygen and, in the presence of polyvinylpyrrolidone(PVP) as biocompatible solubilizer, forms stable micellar saline solutions with theparticles ranged in size between 40 and 100 nm. These nanoparticles representpromising third-generation photosensitizing systems for application in theranostics.
- Добавил в систему: Сергеева Ирина Александровна