Intraosseous injections of platelet rich plasma for knee bone marrow lesions treatment: one year follow-up

Lychagin, A.; Lipina, M.; Garkavi, A.; Islaieh, O.; Timashev, P.; Ashmore, K.; Kon, E.

Авторы: Lychagin A., Lipina M., Garkavi A., Islaieh O., Timashev P., Ashmore K., Kon E.
Журнал: International Orthopaedics
Год издания: 2020
Издательство: Springer Verlag
Местоположение издательства: Germany
DOI: 10.1007/s00264-020-04546-5
Аннотация: PurposeCartilage lesions are usually accompanied by subchondral bone alterations or bone marrow lesions (BMLs).BML associated with joint degeneration and cartilage lesions are considered to be predictors of rapidly progressingOA. Currently no existing treatment can fully halt OA progression. One of the approaches is an autologous,biological treatment based on the use of platelet rich plasma (PRP) injections. The purpose of this study is toassess the short-term effectiveness ofintraosseous PRP injections, withinthe BML of individuals affected by OA,in ameliorating pain and improving knee functionality.Materials and methodsThe study involved 17 patients with an average age of 41.7 ± 14.3 years old. OA stage wasdetermined using the Kellgren-Lawrence grading system by performing radiographic scanning of the knee jointbefore surgical intervention. Patients with K–L grade 3 knee joint OA prevailed. Patient OA history varied betweenone and nine years (average 5.2 ± 4.5 years). Clinical and functional state of the knee were assessed by pain visualanalogue scale (VAS) score, the Western Ontario and McMaster Universities Score (WOMAC), and the Knee Injuryand Osteoarthritis Outcome Score (KOOS) which were filled out by patients previous to the surgical procedure atone, three, six and 12 months post-operatively. Before surgery, in addition to standard blood tests, serum cartilageoligomeric matrix protein (COMP) levels were tested for all patients.ResultsEvaluation of preliminary results revealed a statistically significant reduction of pain based on the VAS score.A significant improvement was also observed in the patients’WOMAC score and in the overall KOOS score. Serummarker levels were initially elevated in our experimental patient group compared to the same marker in healthycontrol respondents, and continued to rise one month and three months following surgery, at six and 12 month thelevel was similar as at three months.
Добавил в систему: Тимашев Петр Сергеевич

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Intraosseous injections of platelet rich plasma for knee bone marrow lesions treatment: one year follow-upстатья

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