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HuR prevents c-fos mRNA degradation by proteasome-associated ribonuclease in vitroстатья
- Авторы: Zhigalova E., Mittenberg A.
- Журнал: Porto Biomedical Journal
- Том: 2
- Номер: 5
- Год издания: 2017
- Первая страница: 217
- Последняя страница: 218
- DOI: 10.1016/j.pbj.2017.07.101
- Аннотация: Proteasome-associated proteins are attractive targets for multiple myeloma treatment. One of them is HuR protein known to selectively bind ARE-containing mRNAs and protect them from degradation. HuR is supposed to play a role in cancerogenesis since its expression is elevated in many cancer types and it stabilizes a lot of mRNAs encoding proteins involved in oncogenesis. Previously, it was shown that proteasome in addition to its main function – protein degradation – may act as a selective RNase. Moreover, HuR and proteasome have common targets – c-myc and c-fos protooncogene mRNAs.
- Добавил в систему: Миттенберг Алексей Георгиевич