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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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The violation of the anticipation processes is the early markers of Parkinson’s diseaseстатья
- Авторы: Nina Danilova*, Marina Nodel, Nikolay Yakhno, Strabykina Elena A., Pligina Anna M.
- Сборник: Фехнер день 2016 – Труды 32-й ежегодной конференции Международного психофизического общества / Под ред. И. Скотниковой, О. Корольковой, И. Блинниковой, В. Дубровского, В. Шендяпина, Н. Волковой. М.:
- Год издания: 2016
- Место издания: Изд-во «Институт психологии РАН», 2016. – 100 с Москва, Россия
- Первая страница: 61
- Последняя страница: 61
- Аннотация: Background: The purpose of this study to identify the cognitive processes in two groups of patients with Parkinson’s disease with different levels of violations. The cognitive processes of patients are compared with two control groups of different age. The attention was directed to the mechanism of anticipation as a special kind of memory and the mechanism of semantic categorization. The experiment included the identification of semantic categories during the visual presented of words belonging to two domains: “animals” and “objects”. Categories of “animals” demanded one motor reaction and categories “objects” – two motor reactions. Methods: The author’s method “Micro structural analysis of oscillatory brain activity”1, which is based on the pacemaker hypothesis of the rhythm genesis, was used to study the cognitive disorders in patients with Parkinson’s disease (PD). The method includes the multi-channel EEG and calculation of equivalent current dipoles for narrowband frequency-selective generators extracted from the evoked potentials. The first group of patients (11 people: 4 males and 7 females, 64–79 years old) with stage of disease 1 and 3 upon Hoehn-Yahr has received the drug – L-dopa alone. The second group of patients with more early stage of PD (11 people: 6 males and 5 females, 47–68 years old) with stage of disease 1 and 2 upon Hoehn-Yahr has received ADR (agonists of dopamine receptors). Results obtained from the patients were compared with two control groups: young (10 people:5 males and 5 females, 22-23years old) and older (10 people: 5 males and 5 females, 50–60 years old). Results: An increase of latent periods of motor responses, the number of errors and the suppression of frequency-selective theta generators activity occurs in both groups of patients when they recognize the category of “animals”. The identification of the category – “animals” is the simple task for the norm groups than for the patients. These changes occur before stimulus in the stage of the anticipation. The group of patients taking the drug L-dopa, has the best performance to Theta generators at the stage of identification of the category – “animals” than patients at an earlier stage of the disease and who has received only agonists dopamine receptors. Conclusions: Violation in anticipation makes it possible to consider this mechanism as an early marker of Parkinson’s disease1. * E-mail: danilovan@mail.ru. The study is funded by RSF project № 14-18-03253. References 1 N. N. Danilova, in: International Congress “Neuroscience for Medicine and Psychology” (Sudak, Crimea, June 2–12, 2015),
- Добавил в систему: Данилова Нина Николаевна