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Complement System Activation by Amyloid Aggregates of Aβ(1-40) and Aβ(1-42) Peptides: Facts and Hypothesesстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 23 сентября 2021 г.
- Авторы: Yakupova E.I., Bobyleva L.G., Vikhlyantsev I.M., Bobylev A.G.
- Журнал: Biophysics
- Том: 65
- Номер: 1
- Год издания: 2020
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 18
- Последняя страница: 21
- DOI: 10.1134/s000635092001025x
- Аннотация: Here, we consider the problem of the activation of the complement system by amyloid aggregates,in particular, amyloid fibrils of the Aβ(1-40) and Aβ(1-42) peptides found in the brain of patients with Alzheimer’sdisease . In 1992, based on the data on colocalization of amyloid inclusions with complement systemproteins in the brains of patients with this disease, it was suggested that this system is directly activated byamyloids. This hypothesis has been supported by a number of subsequent publications. However, in thisstudy, we did not find evidence to support this idea. The issue remains as to whether amyloids activate thecomplement system, and, if not, which mechanism is responsible for its activation. Here, we try to elucidatethese issues.
- Добавил в систему: Якупова Эльмира Ильдаровна