CARBOXYATRACTYLATE INHIBITS THE UNCOUPLING EFFECT OF FREE FATTY-ACIDSстатья

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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.

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[1] Carboxyatractylate inhibits the uncoupling effect of free fatty-acids / A. ANDREYEV, T. BONDAREVA, V. DEDUKHOVA et al. // FEBS Letters. — 1988. — Vol. 226, no. 2. — P. 265–269. The ATP/ADP-antiporter inhibitors and ADP decrease the palmitate-induced stimulation of the mitochondrial respiration in the controlled state. The degree of inhibition decreases in the order: carboxyatractylate > bongkrekic acid, palmitoyl-CoA, ADP > atractylate. GDP is ineffective. The inhibiting concentration of carboxyatractylate coincides with this arresting the state 3 respiration. Carboxyatractylate inhibition decreases when the palmitate concentration increases. Stimulation of controlled respiration by FCCP or gramicidin D at any concentration of these uncouplers is carboxyatractylate-resistant, whereas that by low concentrations of DNP is partially suppressed by carboxyatractylate. These data together with observations that palmitate does not increase H+ conductance in bilayer phospholipid membranes and in cytochrome oxidase-asolectin proteoliposomes indicate that the ATP/ADP-antiporter is somehow involved in the uncoupling by low concentrations of fatty acids (or DNP), whereas that by FCCP and gramicidin D is due to their effect on the phospholipid bilayer. It is suggested that the antiporter facilitates translocation of palmitate anion across the mitochondrial membrane. [ DOI ]

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