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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Evaluation of low-level mercury exposure effects on human healthтезисы доклада
- Авторы: Evstafeva Elena, Zalata Olga, Tymchenko Svetlana, Bogdanova Anna, Evstafeva Irina, Macarova Anna, Yaseneva Elena
- Сборник: The 8th International Conference on Medical Geology
- Тезисы
- Год издания: 2019
- Место издания: Guiyling, China
- Первая страница: 207
- Последняя страница: 208
- Аннотация: This study focused on the evaluation of low level mercury exposure effects onmain parameters of the human body with biomonitoring of hair mercury content inSimferopol population (72 high schoolers, 14-15 year old; 79 students, 18-20 yearold). Mercury content in students – residents of Simferopol was compared to agematched individuals (n = 46) living in other districts of Crimea. Some of thepreliminary results on mercury content in human hair were published (Evstafeva E.V.et al. Environmental and biomonitoring mercury research in the Crimean region,2017). Mercury content in hair was determined by atomic absorption spectrometry(analyzer РА-915М, National Research Tomsk Polytechnic University). Parametersof central and autonomic nervous system and cardiovascular system were examinedby the methods of electroencephalography (EEG), electrocardiography (ECG) andheart rate variability (HRV). HRV measurement was performed by five-minute threelead ECG recordings in supine position and during active tilt test followed byanalyzes of standard time and frequency domain HRV parameters. Higher mentalfunctions were assessed by 2 standard tests: Schulte tables to assess the characteristicsof voluntary attention and Eysenck test for personality evaluation.Mercury hair concentrations in high schoolers (0,13 ± 0,07 (min = 0,06, max =0,3) mkg/g) and students (0,15 ± 0,14 (min = 0,02, max = 0,95) mkg/g) were withinnormal ranges (0,5– 1 mkg/g) with no significant gender difference. Negativeassociations were determined between mercury concentration and total power of lowand average EEG frequencies (0,35<r<0,65; p<0,05) accompanied by prolongedlatency of the N1 and Р300 event related potentials. Individuals with higher mercurylevels showed higher hostility (r = 0,41) and neuroticism (r = 0,37) and were lessmentally stable (r = -0,41) and felt insecure (r = -0,39). Correlation analyses revealedsignificant associations between parameters of voluntary attention and temperament characteristics with mercury content in high schoolers. Identified associationsbetween stress index and mercury levels (r = 0,51) were suggestive for increasedsympathetic activity in high schoolers. In students low level mercury exposure effectson HRV may have been mediated by reduced central influences and were associatedwith reduced sympathetic activity especially in female group.Statistically significantnegative associations between mercury and amplitude of R in II and III standard leadsand in AVF and also negative for the amplitude of T in III standard lead and AVF(0,16<r<0,20; p<0,05) were observed suggesting that mercury exposure may be oneof multiple factors that might influence cardiac activity.These results provideevidence that mercury exposure might play a role in pathogenesis of altered nervousand cardiac activity.This study was funded by RFBR research projects № 18-29-24212\18 (mercury analysis in Simferopol), № 18-45-920042 (mercury analysis inSevastopol).Key words: cardiovascular system, nervous system, mental functions, mercury,Crimea.
- Добавил в систему: Федосеев Андрей Николаевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | 17473726535754.pdf | 17473726535754.pdf | 3,1 МБ | 21 января 2021 [FedoseevAN] |