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CLOCK 3111TT Genotype Is Associated with Increased Total Cholesterol and Low-Density Lipoprotein Levels in Menopausal Women with a Body Mass Index of at Least 25 kg/m2статья
Дата последнего поиска статьи во внешних источниках: 7 июля 2021 г.
- Авторы: Semenova Natalya, Madaeva Irina, Kolesnikov Sergey, Rychkova Lyubov, Bairova Tatjana, Darenskaya Marina, Kolesnikova Lyubov
- Журнал: Pathophysiology
- Том: 28
- Номер: 1
- Год издания: 2020
- Издательство: MDPI Publishing
- Местоположение издательства: Basel, Switzerland, Switzerland
- Первая страница: 1
- Последняя страница: 9
- DOI: 10.3390/pathophysiology28010001
- Аннотация: Abstract: Lipid profile comparative analysis was performed to reveal the interdependence of lipidswith Circadian locomoter output cycles protein kaput (CLOCK) 3111T/C gene polymorphism in menopausal women with/without a body mass index (BMI) of ≥25 kg/m2. Methods: A total of 193 female volunteers aged 45 to 60 years were divided into two groups: Those with BMI < 25 kg/m2(control) and those with BMI ≥ 25 kg/m2. Each group was then divided into two subgroups: Those with the CLOCK TT‐genotype and those with the CLOCK TC‐, CC‐genotypes. Lipid metabolismparameters were determined by the enzymatic method. Single‐nucleotide polymorphisms (SNPs)were detected via polymerase chain reaction–restriction fragment length polymorphism technology. Results: There were no differences in CLOCK 3111T/C genotypes or allele frequency between the control and main groups. In addition, there were no differences in lipid profile parameters between women of the control group and different CLOCK 3111T/C genotypes. The total cholesterol (p = 0.041) and low‐density lipoprotein cholesterol (p = 0.036) levels were higher in the sub‐group of women with a BMI ≥ 25 kg/m2 and CLOCK TT‐genotype as compared to the subgroup with a BMI ≥ 25 kg/m2 and minor allele 3111C. Conclusions: SNP 3111T/C of the CLOCK gene is not associated with BMI however, data suggest that the minor allele of the CLOCK 3111T/C genepolymorphism may have a protective role in atherogenic lipid levels in women with a BMI greater than or equal to 25 kg/m2.
- Добавил в систему: Колесников Сергей Иванович