Role of the ADP/ATP-antiporter in fatty acid-induced uncoupling of Ca2+-loaded rat liver mitochondriaстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:We show that Ca2+ loading of mitochondria substantially augments
the myristate-induced decrease in the transmembrane electric
potential difference (delta psi). Such a Ca2+ action is without effect
on the respiration rate and is not accompanied by the high-amplitude
swelling when low concentrations of Ca2+ and myristate are
used. The myristate-induced delta psi decrease is prevented and reversed
by cyclosporin A (CsA); the decrease is prevented and transiently
reversed by nigericin. To explain these effects, we suggest
that myristate induces opening of the mitochondrial permeability
transition pore at a low-conductance state. Addition of carboxyatractylate
(CAtr) after myristate induces the CsA-sensitive uncoupling,
but when added after myristate and CsA, CAtr produces
a decrease in delta psi, if the interval between myristate and CsA addition
is suf ciently long. The CAtr effect is completely reversed by
EGTA and transiently reversed by nigericin. This suggests that the
ADP/ATP-antiporter participates in the CsA-sensitive uncoupling
when present as a pore complex constituent. ADP/ATP-antiporter
that does not take part in the pore complex formation is involved
in the CsA-insensitive uncoupling.