Intravenous administration of Coenzyme Q10 in acute period of cerebral ischemia decreases mortality by reducing brain necrosis and limiting its increase within 4 days in rat stroke model

Obolenskaya, O.N.; Gorodetskaya, E.A.; Kalenikova, E.I.; Belousova, M.A.; Gulyaev, M.V.; Makarov, V.G.; Pirogov, Y.A.; Medvedev, O.S.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 12 января 2022 г.

Авторы: Obolenskaya O.N., Gorodetskaya E.A., Kalenikova E.I., Belousova M.A., Gulyaev M.V., Makarov V.G., Pirogov Yu A., Medvedev O.S.
Журнал: ANTIOXIDANTS
Том: 9
Номер: 12
Год издания: 2020
Первая страница: 1
Последняя страница: 17
Номер статьи: 1240
DOI: 10.3390/antiox9121240
Аннотация: Background: Oxidative stress plays a key role in the 16pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting 17effect and may protect the brain against ischemic damage. The aim of 18our study was to evaluate the neuroprotective potential of ubiquinol by19its intravenous administration. Methods: The study was performed on 20rats, a stroke was modeled by occlusion of the middle cerebral artery. On days 1 and 4 after ischemia, the neurological deficit and the volume of the brain lesion were determined by MRI and TTC staining. Results: Intravenous dministration of coenzyme Q10 led to a decrease in ratsmortality rate, an improvement in neurological status, and a decrease in the brain necrosis area in acute and delayed period after cerebral ischemia. A single intravenous administration of ubiquinol led to a imitation of the size of the brain damage for at least 4 days after ischemia. Conclusions: Thus, intravenous administration of coenzyme Q10 had a persistent neuroprotective potential. This finding suggests a possible therapeutic role of ubiquinol in acute ischemic conditions.Keywords: coenzyme Q10, ubiquinol, ubiquinone, brain ischemia, neuroprotection, stroke, antioxidant.
Добавил в систему: Каленикова Елена Игоревна

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Intravenous administration of Coenzyme Q10 in acute period of cerebral ischemia decreases mortality by reducing brain necrosis and limiting its increase within 4 days in rat stroke modelстатья

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