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Variation in tumor pH affects pH-triggered delivery of peptide-modified magnetic nanoparticlesстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 ноября 2020 г.
- Авторы: Pershina Alexandra G., Brikunova Olga Ya, Demin Alexander M., Abakumov Maxim A., Vaneev Alexander N., Naumenko Victor A., Erofeev Alexander S., Gorelkin Peter V., Nizamov Timur R., Muslimov Albert R., Timin Alexander S., Malkeyeva Dina, Kiseleva Elena, Vtorushin Sergey V., Larionova Irina V., Gereng Elena A., Minin Artem S., Murzakaev Aidar M., Krasnov Victor P., Majouga Alexander G., Ogorodova Ludmila M.
- Журнал: Nanomedicine: Nanotechnology, Biology, and Medicine
- Том: 32
- Год издания: 2020
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Номер статьи: 102317
- DOI: 10.1016/j.nano.2020.102317
- Аннотация: Acidification of the extracellular matrix, an intrinsic characteristic of many solid tumors, is widely exploited for physiologically triggered delivery of contrast agents, drugs, and nanoparticles to tumor. However, pH of tumor microenvironment shows intra- and inter-tumor variation. Herein, we investigate the impact of this variation on pH-triggered delivery of magnetic nanoparticles (MNPs) modified with pH-(low)-insertion peptide (pHLIP). Fluorescent flow cytometry, laser confocal scanning microscopy and transmission electron microscopy data proved that pHLIP-conjugated MNPs interacted with 4T1 cells in two-dimensional culture and in spheroids more effectively at pH 6.4 than at pH 7.2, and entered the cell via clathrin-independent endocytosis. The accumulation efficiency of pHLIP-conjugated MNPs in 4T1 tumors after their intravenous injection, monitored in vivo by magnetic resonance imaging, showed variation. Analysis of the tumor pH profiles recorded with implementation of original nanoprobe pH sensor, revealed obvious correlation between pH measured in the tumor with the amount of accumulated MNPs.
- Добавил в систему: Ванеев Александр Николаевич