Study of the Microtubule-Paclitaxel Interaction in vitro and in silico

Авторы: Vovchenko M., Aleksandrova V., Mustyatsa V., Gudimchuk N.
Сборник: Proceedings of the International Conference "Mathematical Biology and Bioinformatics"
Год издания: 2020
Место издания: IMPB RAS - Branch of KIAM RAS Pushchino
Номер статьи: e31
DOI: 10.17537/icmbb20.30
Аннотация: Microtubules are dynamic polymers of tubulin that play an important role in the process of cell division. One of their main features is a stochastic nature of transitions from growth to shrinkage. Paclitaxel is an anticancer chemotherapy drug, known to stabilize microtubule by suppressing their dynamic instability. Inhibition of microtubule dynamics induced by paclitaxel leads to cell cycle arrest. To investigate the mechanism of paclitaxel action on microtubules, we performed a series of in vitro experiments on microtubules assembly in the presence of paclitaxel, and used computer modeling to simulate this process. Several scenarios of the paclitaxel molecule attachment to the microtubule and its effect on tubulin dimers were tested. Our model describes the paclitaxel-induced stabilization of microtubules. The model can be elaborated in the future for a more detailed examination of this process, which is necessary for improving cancer therapy with paclitaxel.
Добавил в систему: Вовченко Максим Александрович

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