New composite stationary phase for chiral high-performance liquid chromatography

Prosuntsova, D.S.; Plodukhin, A.Y.; Ananieva, I.A.; Beloglazkina, E.K.; Nesterenko, P.N.

Авторы: Prosuntsova D.S., Plodukhin A.Yu, Ananieva I.A., Beloglazkina E.K., Nesterenko P.N.
Журнал: Journal of Porous Materials
Том: 28
Год издания: 2021
Издательство: Springer Nature
Местоположение издательства: Switzerland
Первая страница: 407
Последняя страница: 414
DOI: 10.1007/s10934-020-00985-y
Аннотация: The new composite chiral stationary phase for high-performance liquid chromatography was prepared and characterized. Poly(styrene-divinylbenzene) microspherical particles with diameter of 3.3 micron were used as a matrix and coated with layer of 10 nm gold nanoparticles. Immobilized gold nanoparticles increased specific surface area of adsorbent and simplify covalent attachment of sulfur-containing compounds. In this work L-lysine conjugate with lipoic acid was synthesized, characterized and used for modification of gold nanoparticles. The prepared chiral selector was immobilized by the reaction of sulfur-containing groups from lipoic acid residue with gold surface of nanoparticles with formation of self-assembled monolayer. The prepared chiral stationary phase was characterized by nitrogen adsorption at low temperatures, diffuse reflection spectroscopy, scanning electron microscopy. The chromatographic retention of beta-blockers and profens was studied under conditions of reversed-phase HPLC. The possibility of enantiomers separation was demonstrated for flurbiprofen and ketoprofen racemates using 100 × 4.6 mm ID chromatographic column.
Добавил в систему: Плодухин Андрей Юрьевич

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