The role of arginine-vasopressin receptor gene polymorphisms in the development of anger-related traitsстатья
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Дата последнего поиска статьи во внешних источниках: 2 декабря 2020 г.
Аннотация:Anger is an emotional reaction to threat, frustration or social provocation, which modulates an individual’s risk for aggression. Molecular-genetic studies demonstrated the involvement of arginine-vasopressin system in affective psychopathology. However, many of them lack the analysis of G 9E-interactions thus providing controversial findings. The present study aimed to estimate the main effect of AVPR1A (rs1042615, rs3803107) and AVPR1B (rs28632197, rs33911258) gene polymorphisms, as well as G9E effects on anger-related traits in healthy individuals.The study involved 623 mentally healthy individuals from the Russian Federation (81.11% women; mean age 19.53±1.75 years). All participants were of Caucasian origin of several ethnic groups: Russians (N = 225), Udmurts (N = 218) and Tatars (N = 180). Anger-related traits were assessed using Anger Scale of the Buss Perry Aggression Questionnaire (BPAQ-29). SNPs genotyping was per-formed used Real-Time PCR. Statistical analysis was conducted with PLINK v.1.9 followed by FDR correction for multiple testing. Statistical analysis revealed an association of AVPR1A*rs3803107 T-allele (PFDR= 0.03; r²= 0.01) and AVPR1B*rs33911258 G-allele (PFDR = 0.03; r²= 0.01) and decreased anger. Multiple regression analysis demonstrated that smoking (PFDR = 0.01; r²= 0.16), birth season (PFDR= 0.04; r²= 0.04) and place of residence (PFDR= 0.04; r²= 0.02) significantly modulated association of AVPR1B*rs33911258 and anger, while birth season (PFDR= 0.03; r²= 0.05) significantly modulated association on the AVPR1A*rs3803107and anger in total sample. Our findings provide evidence for specific effect of several environmental factors (smoking, birth season and place of residence) on the associations AVPR1Aand AVPR1Bgene polymorphisms and anger-related traits.