Neoteny, Prolongation of Youth: from Naked Mole Rats to "Naked Apes" (Humans)статья

Статья опубликована в высокорейтинговом журнале

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Дата последнего поиска статьи во внешних источниках: 1 апреля 2017 г.

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[1] Neoteny, prolongation of youth: from naked mole rats to "naked apes" (humans) / S. Vladimir, H. Susanne, V. Mikhail et al. // Physiological Reviews. — 2017. — Vol. 97, no. 2. — P. 699–720. It has been suggested that highly social mammals, such as naked mole rats and humans, are long-lived due to delays of their aging program via neoteny (the elongation of youth). In both species, aging cannot operate as a mechanism facilitating natural selection because the pressure of this selection is strongly reduced (i) due to a specific social structure where only the “queen” and her “husband(s)” are involved in reproduction (naked mole rats) or (ii) by substituting fast technical progress for slow biological evolution (humans). Lists of numerous traits of youth that do not disappear with age in both naked mole rats and in humans are presented and discussed. A high resistance of naked mole rats to cancer, diabetes, cardiovascular and brain diseases, and many infections, explains why their mortality rate is very low and apparently age-independent and why their lifespan is more than 32 years, vs. 3 years in mice. In young humans, curves of mortality vs. age start at extremely low values. However, in the elderly, human mortality strongly increases. High mortality rates in other primates occur at much younger ages than in humans. The inhibition of the aging program in humans by antiaging drugs seems to be a promising approach to prolong our healthspan. In this way, we may solve the problem of the elimination of aging which is already partially accomplished via the natural physiological phenomenon of human neoteny. [ DOI ]

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