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Beilunmycin, a new virginiamycins antibiotic from mangrove-derived Streptomyces sp. 2BBP-J2 and the antibacterial activity by inhibiting protein translationстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 21 октября 2020 г.
- Авторы: Zhong-Ke Jiang, Hu Xin-Xin, Xiao Lan-Lin, Ren Yi-Ru, Shakhtina Anna N., Lukianov Dmitrii A., Osterman Ilya A., Sergiev Petr V., Dontsova Olga A., Wang Hao, Wu Gang, You Xue-Fu, Sun Cheng-Hang
- Журнал: Journal of Asian Natural Products Research
- Год издания: 2020
- Издательство: Taylor & Francis
- Местоположение издательства: United Kingdom
- Первая страница: 1
- Последняя страница: 9
- DOI: 10.1080/10286020.2020.1810669
- Аннотация: One new virginiamycin derivative, ‘beilunmycin’ (1), and three known virginiamycin antibiotics, 16-hydroxy-virginiamycin M1 (2), virginiamycin M2 (3), and virginiamycin M1 (4), were isolated from the culture of a mangrove-derived endophytic Streptomyces sp. 2BBP-J2. The structures were characterized on the basis of their spectroscopic data, and the absolute configuration of 1 was established by ECD calculations. Compounds 1–4 exhibited antibacterial activities against Gram-positive bacteria, with MIC values in the range of 0.5–16 μg/ml. All the compounds demonstrated strong protein translation-stalling activity, with minimal concentrations detected with pDualrep2 in the range of 1.9–5.9 nmol.
- Добавил в систему: Лукьянов Дмитрий Александрович