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Macro-, Micro- and Nano-Roughness of Carbon-Based Interface with the Living Cells: Towards a Versatile Bio-Sensing Platformстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 25 ноября 2020 г.
- Авторы: Golubewa Lena, Rehman Hamza, Kulahava Tatsiana, Karpicz Renata, Baah Marian, Kaplas Tommy, Shah Ali, Malykhin Sergei, Obraztsov Alexander, Rutkauskas Danielis, Jankunec Marija, Matulaitiene Ieva, Selskis Algirdas, Denisov Andrei, Svirko Yuri, Kuzhir Polina
- Журнал: Sensors
- Том: 20
- Год издания: 2020
- Издательство: MDPI
- Местоположение издательства: Basel, Switzerland
- Первая страница: 1
- Последняя страница: 14
- Номер статьи: 5028
- DOI: 10.3390/s20185028
- Аннотация: Integration of living cells with nonbiological surfaces (substrates) of sensors, scaffolds,and implants implies severe restrictions on the interface quality and properties, which broadlycover all elements of the interaction between the living and artificial systems (materials, surfacemodifications, drug-eluting coatings, etc.). Substrate materials must support cellular viability,preserve sterility, and at the same time allow real-time analysis and control of cellular activity.We have compared new substrates based on graphene and pyrolytic carbon (PyC) for the cultivationof living cells. These are PyC films of nanometer thickness deposited on SiO2 and black silicon andgraphene nanowall films composed of graphene flakes oriented perpendicular to the Si substrate.The structure, morphology, and interface properties of these substrates are analyzed in terms oftheir biocompatibility. The PyC demonstrates interface biocompatibility, promising for controllingcell proliferation and directional intercellular contact formation while as-grown graphene wallspossess high hydrophobicity and poor biocompatibility. By performing experiments with C6glioma cells we discovered that PyC is a cell-friendly coating that can be used without poly-l-lysineor other biopolymers for controlling cell adhesion. Thus, the opportunity to easily control thephysical/chemical properties and nanotopography makes the PyC films a perfect candidate for thedevelopment of biosensors and 3D bioscaffolds.
- Добавил в систему: Образцов Александр Николаевич