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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Ouabain Modulates the Functional Interaction Between Na,K-ATPase and NMDA Receptorстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Akkuratov Evgeny E., Westin Linda, Vazquez-Juarez Erika, de Marothy Minttu, Melnikova Aleksandra K., Blom Hans, Lindskog Maria, Brismar Hjalmar, Aperia Anita
- Журнал: Molecular Neurobiology
- Год издания: 2020
- Издательство: Humana Press, Inc.
- Местоположение издательства: United States
- DOI: 10.1007/s12035-020-01984-5
- Аннотация: The spatial colocalization between NMDA receptors and the Na,K-ATPase catalytic subunits on dendrites of cultured rat hippocampal neurons was analyzed with super-resolution dSTORM microscopy. The functional interaction was analyzed with calcium imaging of single hippocampal neurons exposed to 10 μM NMDA in presence and absence of ouabain and by determination of the ouabain effect on NMDA receptor-dependent long-term potentiation. We show that NMDA receptors and the Na,K-ATPase catalytic subunits alpha1 and alpha3 exist in same protein complex and that ouabain in nanomolar concentration consistently reduces the calcium response to NMDA.
- Добавил в систему: Мельникова Александра Кирилловна