Bovine serum albumin adsorbed on eremomycin and grafted on silica as new mixed-binary chiral sorbent for improved enantioseparation of drugsстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 30 декабря 2016 г.
Аннотация:A new silica-based, mixed-binary chiral sorbent grafted with the macrocyclic antibiotic
eremomycin and bovine serum albumin (BSA) was obtained. The sorbent-filled high performance
liquid chromatography column was capable of enantioseparation of racemic drugs, such as profens, in reversed-phase-chromatography mode. The mixed-binary eremomycin-BSA-sorbent showed better capability for profens enantioseparation as compared with a sorbent containing eremomycin only. BSA grafted onto the sorbent surface significantly reduced retention times of other proteins from the analyte solution,
and free proteins (including BSA) injected as analytes were not retained on the column, and
subsequently eluted with a dead volume. The drastic difference observed in the binding of
profens and other proteins using the sorbent was tested for determination and enantioseparation
of profens in artificial-urine solutions.