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Mitochondrial Ca2+ cycle mediated by the palmitate-activated cyclosporin A-insensitive poreстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 октября 2016 г.
- Авторы: Mironova Galina D., Belosludtsev Konstantin N., Belosludtseva Natalia V., Gritsenko Elena N., Khodorov Boris I., Saris Nils-Erik L.
- Журнал: Journal of Bioenergetics and Biomembranes
- Том: 39
- Номер: 2
- Год издания: 2007
- Издательство: Springer/Plenum Publishers
- Местоположение издательства: New York, USA
- Первая страница: 167
- Последняя страница: 174
- DOI: 10.1007/s10863-007-9079-9
- Аннотация: Earlier we found that in isolated rat liver mitochondria the reversible opening of the mitochondrial cyclosporin A-insensitive pore induced by low concentrations of palmitic acid (Pal) plus Ca2+ results in the brief loss of Delta psi [Mironova et al., J Bioenerg Biomembr (2004), 36:171-178]. Now we report that Pal and Ca2+, increased to 30 and 70 nmol/mg protein respectively, induce a stable and prolonged (10 min) partial depolarization of the mitochondrial membrane, the release of Ca2+ and the swelling of mitochondria. Inhibitors of the Ca2+ uniporter, ruthenium red and La3+, as well as EGTA added in 10 min after the Pal/Ca2+ -activated pore opening, prevent the release of Ca2+ and repolarize the membrane to initial level. Similar effects can be observed in the absence of exogeneous Pal, upon mitochondria accumulating high [Sr2+], which leads to the activation of phospholipase A(2) and appearance of endogenous fatty acids. The paper proposes a new model of the mitochondrial Ca2+ cycle, in which Ca2+ uptake is mediated by the Ca2+ uniporter and Ca2+ efflux occurs via a shortliving Pal/Ca2+-activated pore.
- Добавил в систему: Белослудцев Константин Николаевич