Аннотация:The high sensitivity of modern techniques for lifetime detection opens new significantopportunities for investigation of various processes in the biological media. Here, we report onthe novel sub-class of cyanine dyes. We examined the effect of electronic coupling on the opticalproperties of the complex of the dye with the human serum albumin. TCSPC measurements offluorescence decay provided evidence that the studied dye generates more than two kinds ofcomplexes with albumin. It was established that the effect of “frozen structure” in complexchanges the rate of photoisomerization way of the dye’s excited state degradation. Furthermore,by means of molecular docking, the experimentally proposed mechanism of complex formationand the existence of several binding sites were confirmed.
