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Rigorous Mathematical Analysis of the Quasispecies Model: From Manfred Eigen to the Recent Developmentsстатья
Информация о цитировании статьи получена из
Web of Science
Дата последнего поиска статьи во внешних источниках: 21 октября 2020 г.
- Авторы: Bratus Alexander S., Novozhilov Artem S., Semenov Yuri S.
- Сборник: Advanced mathematical methods in biosciences and applications
- Серия: STEAM-H: Science, Technology, Engineering, Agriculture, Mathematics & Health
- Год издания: 2019
- Место издания: Springer Cham
- Первая страница: 27
- Последняя страница: 51
- DOI: 10.1007/978-3-030-15715-9
- Аннотация: We review the major progress in the rigorous analysis of the classical quasispecies model that usually comes in two related but different forms: the Eigen model and the Crow–Kimura model. The model itself was formulated almost 50 years ago, and in its stationary form represents an easy to formulate eigenvalue problem. Notwithstanding the simplicity of the problem statement, we still lack full understanding of the behavior of the mean population fitness and the quasispecies distribution for an arbitrary fitness landscape. Our main goal in this review is twofold: first, to highlight a number of impressive mathematical results, including some of the recent ones, which pertain to the mathematical development of the quasispecies theory. Second, to emphasize that, despite these 50 years of vigorous research, there are still very natural both biological and mathematical questions that remain to be addressed within the quasispecies framework. Our hope is that at least some of the approaches we review in this text can be of help for anyone embarking on further analysis of the quasispecies model.
- Добавил в систему: Дрожжин Сергей Вячеславович