Complex formation of albumin with tricarbocyanine dyes containing phosphonate groupsстатья

Информация о цитировании статьи получена из Scopus, Web of Science
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Дата последнего поиска статьи во внешних источниках: 9 декабря 2016 г.

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[1] Complex formation of albumin with tricarbocyanine dyes containing phosphonate groups / V. A. Kuzmin, T. D. Nekipelova, T. A. Podrugina et al. // Photochemical and Photobiological Sciences. — 2016. — Vol. 15, no. 11. — P. 1377–1384. The complex formation of novel dyes of the tricarbocyanine family with remote P-containing groups at 3,3′-positions of nitrogen atoms and BSA and HSA were studied by absorption and emission spectrometry and the binding constants were determined. The experimental results and theoretical docking of the dyes in the structures of protein molecules strongly indicate the principal role of the hydrophobic interactions of the dye polymethine chain with protein binding sites in complex formation. The formation of two types of complexes between dyes under study and albumin has been shown. One of these complexes with a longer lifetime of fluorescence is the complex of the dye molecule located in the more hydrophobic site and that with the shorter fluorescence lifetime is located in the more hydrophilic site of the protein. The increase in the lifetime of the excited singlet state in the former complex indicates the formation of a more rigid structure of the dye in this complex as compared with the latter complex. Thus, tricarbocyanine dyes with remote phosphonate groups at 3,3′-positions of nitrogen atoms, especially with ethoxyphosphonate groups, may be considered as promising fluorescent probes for albumin detection. [ DOI ]

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