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19F MRI of human lungs at 0.5 Tesla using octafluorocyclobutaneстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 мая 2020 г.
- Авторы: Pavlova O.S., Anisimov N.V., Gervits L.L., Gulyaev M.V., Semenova V.N., Pirogov Yu A., Panchenko V.Ya
- Журнал: Magnetic Resonance in Medicine
- Том: 84
- Номер: 4
- Год издания: 2020
- Издательство: John Wiley & Sons Inc.
- Местоположение издательства: United States
- Первая страница: 2117
- Последняя страница: 2123
- DOI: 10.1002/mrm.28270
- Аннотация: Purpose: The aim of this study was to demonstrate the feasibility of fluorine-19(19F) MRI of the human lungs using octafluorocyclobutane (OFCB, C4F8). This gashas 8 magnetically equivalent fluorine nuclei and relatively long T1 and T2 (~50 ms),which render it suitable as an MRI contrast agent. Previous experiments in smalllaboratory animals showed that OFCB could be successfully used as an alternative tothe gases often used for 19F MRI (sulfur hexafluoride and perfluoropropane).Methods: One male volunteer participated in this study. Immediately before an MRIscan, the volunteer inhaled the gas mixture—80% OFCB with 20% oxygen—andheld his breath. Experiments were performed on a 0.5T whole-body MR scannerwith a customized transmit–receive coil tuned at 19F frequency. Fast spin echo in2D and 3D modes was used for image acquisition. 2D images were obtained within-plane resolution of 10 × 10 mm2 without slice selection. 3D images were obtainedwith the voxel size of 10 × 10 × 30 mm2. Breath-hold duration was 20 s for 2D and40 s for 3D imaging, respectively.Results: Anatomically consistent 19F MR images of the human lungs were obtainedwith SNR around 50 in 2D mode and 20 in 3D mode. 3D volumetric images of thelungs were reconstructed and provided physiologically reasonable volume estimates.Conclusion: The application of OFCB enables informative 19F lung imaging even atlow magnetic field strengths. The OFCB gas shows promise as an inhalable contrastagent for fluorine lung MRI and has a potential for clinical translation.
- Добавил в систему: Анисимов Николай Викторович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Иллюстрация | Обложка журнала | Pages_from_MRM_84_4.pdf | 2,5 МБ | 7 октября 2020 [Nabla] |
| 2. | Полный текст | mrm.28270.pdf | 523,0 КБ | 30 июня 2020 [nico-06-11] | |
| 3. | razreshenie_legkie_50T_2020.pdf | razreshenie_legkie_50T_2020.pdf | 141,3 КБ | 24 февраля 2021 [GervitsL.L.] |