Translation-Targeting RiPPs and Where to Find Them

Авторы: Travin Dmitrii, Bikmetov Dmitry, Severinov Konstantin
Журнал: Frontiers in genetics
Том: 11
Номер: 226
Год издания: 2020
Издательство: Frontiers Research Foundation.
Местоположение издательства: Lausanne, Switzerland
DOI: 10.3389/fgene.2020.00226
Аннотация: Prokaryotic translation is among the major targets of diverse natural products with antibacterial activity including several classes of clinically relevant antibiotics. In this review, we summarize the information about the structure, biosynthesis, and modes of action of translation inhibiting ribosomally synthesized and post-translationally modified peptides (RiPPs). Azol(in)e-containing RiPPs are known to target translation, and several new compounds inhibiting the ribosome have been characterized recently. We performed a systematic search for biosynthetic gene clusters (BGCs) of azol(in)econtaining RiPPs. This search uncovered several groups of clusters that likely direct the synthesis of novel compounds, some of which may be targeting the ribosome.
Добавил в систему: Травин Дмитрий Юрьевич

	ИСТИНА	Войти в систему Регистрация
	Интеллектуальная Система Тематического Исследования НАукометрических данных
	Главная Поиск Статистика О проекте Помощь

ИСТИНА