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ANTIMUTAGENIC ACTIVITY OF BACTERIAL-CELL EXTRACTS ON MUTAGENESIS INDUCED BY 2-NITROFLUORENE IN STRAINS OF SALMONELLA-TYPHIMURIUMстатья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: VOROBEVA LI, CHERDYNTSEVA TA, ABILEV SK
- Журнал: Genetika
- Том: 31
- Номер: 7
- Год издания: 1995
- Издательство: Izdatel'stva Nauka
- Местоположение издательства: Russian Federation
- Первая страница: 901
- Последняя страница: 907
- Аннотация: It was shown that cell extracts and cells of Streptococcus faecalis decrease the mutagenic effect of 2-nitrofluorene in Salmonella typhimurium strain TA1538 by 73 and 48%, respectively. Cell extracts and cells of Bifido-bacterium bifidum and Propionibacterium shermanii exhibited weak antimutagenic activity. No antimutagenic effect was found in Escherichia coli AB1157, Lactobacillus delbrueckii, or Streptococcus; thermophilus. Antimutagenicity of the cell extract of Str. faecalis is both associated with extracellular factors interacting with 2-nitrofluorene (desmutagensis) and with factors affecting intracellular processes of mutagen biotransformation and mutation induction. Thiol compounds produced by growing Str. faecalis may be desmutagenic factors. A relatively heat-stable substance or substances of a peptide nature with a MM less than 12 kDa are antimutagenic factors affecting intracellular processes of mutagenesis.
- Добавил в систему: Воробьева Лена Ивановна