|
ИСТИНА |
Войти в систему Регистрация |
Интеллектуальная Система Тематического Исследования НАукометрических данных |
||
DNA sequence-specific ligands. XVIII. Synthesis, physico-chemical properties, genetic, virological, and biochemical studies of fluorescent dimeric bisbenzimidazoles DBPA(n)статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 апреля 2020 г.
- Авторы: Koval Vasiliy S., Arutyunyan Albert F., Salyanov Victor I., Kostyukov Alexey A., Melkina Olga E., Zavilgelsky Gennadii B., Klimova Regina R., Kushch Alla A., Korolev Sergey P., Agapkina Yulia Yu, Gottikh Marina B., Vaiman Andrey V., Rybalkina Ekaterina Yu, Susova Olga Yu, Zhuze Alexei L.
- Журнал: Bioorganic and Medicinal Chemistry
- Год издания: 2020
- Издательство: Pergamon Press Ltd.
- Местоположение издательства: United Kingdom
- Первая страница: 115378
- DOI: 10.1016/j.bmc.2020.115378
- Аннотация: A set of AT-specific fluorescent dimeric bisbenzimidazoles DBPA(n) with linkers of different lengths bound to DNA in the minor groove were synthesized and their genetic, virological, and biochemical studies were performed. The DBPA(n) were shown to be effective inhibitors of the histon-like protein H-NS, a regulator of the DNA transcription factor, as well as of the Aliivibrio logei Quorum Sensing regulatory system in E. coli cells. Their antiviral activity was tested in model cell lines infected with herpes simplex virus type I. Also, it was found that DBPA(n) could inhibit catalytic activities of HIV-1 integrase at low micromolar concentrations. All of the dimeric bisbenzimidazoles DBPA(n) manifested fluorescent properties, were well soluble in water, nontoxic up to concentrations of 200 µM, and could penetrate into nuclei followed by binding to DNA.
- Добавил в систему: Костюков Алексей Александрович