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The neurogenic constrictor response of isolated rat saphenous artery is reduced after 2-week tail suspensionстатья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Golubinskaya V., Tarasova O., Borovik A., Vinogradova O.
- Журнал: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
- Том: 8
- Номер: 1
- Год издания: 2001
- Издательство: Galileo Foundation
- Местоположение издательства: El Cerrito, CA, United States
- Первая страница: P55
- Последняя страница: P56
- Аннотация: Under real or simulated microgravity conditions the control of arterial vascular tone is greatly disturbed. The low arterial vessel reactivity to sympathetic influences may be the cause of an increase in flow in hind limb skeletal muscles in tail-suspended (TS) rats. Our previous experiments with constant pressure perfusion of rat hind limb demonstrated the reduced vasoconstrictor responses to sympathetic nerve stimulation in TS rats. Responses to exogenous noradrenaline depended on the perfusion conditions. It is known that the vessels of various branching orders noticeably differ in nerve density and in sensitivity to vasoconstrictor agonists. So under neurogenic or exogenous noradrenaline influences the vascular resistance may be increased at different levels of vascular bed, thus making the data analysis seriously complicated. This uncertainty may be overcome by investigation of a single vessel isolated from hind limb vascular bed. The saphenous artery, a resistance artery with dense innervation, is a very convenient object for this purpose. Thus, this study was aimed at comparing the effects of 2-week tail suspension upon the constrictor responses of isolated saphenous artery to neurogenic and exogenous noradrenaline stimuli in rats.
- Добавил в систему: Тарасова Ольга Сергеевна