Influence of the hepatitis C virus 3'-untranslated region on IRES-dependent and cap-dependent translation initiationстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Translation of hepatitis C virus (HCV) genomic RNA is directed by an internal
ribosome entry site (IRES) in the 5'-untranslated region (5'-UTR), and the HCV
3'-UTR enhances IRES activity. Since the HCV 3'-UTR has a unique structure among
3'-UTRs, we checked possible communication between the 5'- and the 3'-UTR of HCV
during translation using chimeric reporter RNAs. We show that translation
directed by the HCV IRES and by the HCV-like IRES of porcine teschovirus (PTV)
which belongs to a quite distinct family of viruses (picornaviruses) or by the
EMCV IRES is also enhanced by the HCV 3'-UTR or by a poly(A)-tail in different
cell types.