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Интеллектуальная Система Тематического Исследования НАукометрических данных |
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Chemokines, cytokines and exosomes help tumors to shape inflammatory microenvironmentстатья
Статья опубликована в высокорейтинговом журнале
Статья опубликована в журнале из списка Web of Science и/или Scopus- Авторы: Atretkhany KN, Drutskaya MS, Nedospasov SA, Grivennikov SI, Kuprash DV
- Журнал: Pharmacology and Therapeutics
- Год издания: 2016
- Издательство: Pergamon Press
- Местоположение издательства: United States
- DOI: 10.1016/j.pharmthera.2016.09.011
- Аннотация: Relationship between inflammation and cancer is now well-established and represents a paradigm that our immune response does not necessarily serves solely to protect us from infections and cancer. Many specific mechanisms that link chronic inflammation to cancer promotion and metastasis have been uncovered in the recent years. Here we are focusing on the effects that tumors may exert on inflammatory cascades, tuning the immune system ability to cause tumor promotion or regression. In particular, we discuss the contributions of chemokines, cytokines and exosomes to the processes such as induction of inflammation and tumorigenesis. Overall, tumor-elicited inflammation is a key driver of tumor progression and an essential component of tumor microenvironment.
- Добавил в систему: Несмиянов Павел Павлович