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Cytotoxic properties of rhenium(I) tricarbonyl complexes supported by S,N,S'-pincer ligandsстатья
Статья опубликована в журнале из списка RSCI Web of Science
- Авторы: Kozlov V.A., Churusova S.G., Rybalkina E.Yu, Peregudov A.S., Denisov G.L., Aleksanyan D.V.
- Журнал: ИНЭОС OPEN
- Том: 2
- Номер: 5
- Год издания: 2019
- Издательство: Федеральное государственное бюджетное учреждение науки Институт элементоорганических соединений им. А. Н. Несмеянова Российской академии наук
- Местоположение издательства: Москва
- Первая страница: 172
- Последняя страница: 177
- Аннотация: Three Re(I) tricarbonyl complexes were readily obtained by the direct cyclometalation of non-classical pincer ligands based on functionalized amides which combine thiophosphoryl and thioether pendant arms. Realization of κ3-S,N,S'-coordination in the resulting compounds was confirmed by multinuclear NMR and IR spectroscopy and, in the case of the phenylmercaptoacetyl derivative, also by X-ray crystallography. The complexes obtained were screened for cytotoxicity against human colon (HCT116), prostate (PC3), and breast (MCF7) cancer cell lines and exhibited moderate to good activity. The complexes bearing neomenthylmercaptoacetyl and methylmercaptobenzoyl coordination arms provided the same efficiency as a reference, cisplatin, in cancer cells, but were more selective towards human embryonic kidney cells HEK293, which were used as a representative of healthy cell lineages. Furthermore, the Re(I) pincer complex bearing a phenyl substituent at the thioether group exhibited promising activity against a doxorubicin-resistant subline of breast transformed cells HBL100.
- Добавил в систему: Алексанян Диана Владимировна
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