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Myogenic response of rat femoral small arteries in relation to wall structure and [Ca2+](i)статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 20 сентября 2013 г.
- Авторы: Matchkov V.V., Tarasova O.S., Mulvany M.J., Nilsson H.
- Журнал: American Journal of Physiology - Heart and Circulatory Physiology
- Том: 283
- Номер: 1
- Год издания: 2002
- Издательство: American Physiological Society
- Местоположение издательства: United States
- Первая страница: H118
- Последняя страница: H125
- DOI: 10.1152/ajpheart.00690.2001
- Аннотация: The present study investigated the influence of media thickness on myogenic tone and intracellular calcium concentration ([Ca2+](i)) in rat skeletal muscle small arteries. A ligature was loosely tied around one external iliac artery of 5-wk-old spontaneously hypertensive rats. At 18 wk of age, femoral artery blood pressure was 102 +/- 11 mmHg (n = 15) on the ligated side and 164 +/- 6 mmHg (n = 15) on the contralateral side. Small arteries feeding the gracilis muscle had a reduced media cross-sectional area and a reduced media-to-lumen ratio on the ligated side, where also the range of myogenic constriction was shifted to lower pressures. However, when expressed as a function of wall stress, diameter responses were nearly identical. [Ca2+](i) was higher in vessels from the ligated hindlimb at pressures above 10 mmHg, but vasoconstriction was not accompanied by changes in [Ca2+](i). Thus the myogenic constriction here seems due primarily to changes in intracellular calcium sensitivity, which are determined mainly by the force per cross-sectional area of the wall and therefore altered by changes in vascular structure.
- Добавил в систему: Тарасова Ольга Сергеевна