Аннотация:Aim. Human laterality - a preference or higher locomotive or sensor performance is a multidimensional trait (Rigal, 1992). Few studies focused on the link between crossed laterality and brain pathologies, like Parkinson's disease (PD) causing both motor and cognitive disturbances. The aim of the study was to precise brain mechanisms of PD through its comprehensive (neuropsychological, psychophysiological and neurological) study. Material and methods. 11 PD patients (4 males and 7 females, 47–68 years old, all right handed) with initial stage of disease (1 and 2 upon Hoehn-Yahr) had a comprehensive neuropsychological and neurological assessment using Luria's battery, laterality profile, EEG registration, Stroop test, depression, anxiety and apathy measures. Results All but one patients had crossed laterality. Types of crossed laterality differently correlated with patterns of cognitive, emotional, psychophysiological and neurological symptoms. Conclusion Crossed laterality is a significant pathological factor The study is founded by RSF project #14-18-03253