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[Probable compact structure of a cis-active translation element in the 5'-untranslated region of the enterovirus and rhinovirus genome]статья
Информация о цитировании статьи получена из
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Pilipenko E.V., Maslova S.V., Agol V.I.
- Журнал: Molekuliarnaia biologiia
- Том: 26
- Номер: 3
- Год издания: 1992
- Издательство: Russian Academy of Sciences
- Местоположение издательства: Russian Federation
- Первая страница: 565
- Последняя страница: 572
- Аннотация: A previously proposed consensus secondary structure model of the internal portion of the 5'-untranslated region of the enterovirus and rhinovirus genomes encompassing the cis-acting translational control element was extended and detailed on the basis of comparative sequence data and biochemical analysis. Using this model as a reference, numerous pairs of apparently single-stranded noncontiguous nucleotide stretches with a potential to form inter-domain tertiary bonds were shown to be conserved among the respective segments of all the known enterovirus and rhinovirus RNAs. It is suggested that at least some of these inter-domain bonds may actually exist, resulting in a compact, quasi-globular, perhaps "two-lobe" folding of the translational control element. Such an organization should have important functional implications.
- Добавил в систему: Агол Вадим Израилевич