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SELECTIVE PROTECTION OF CELLS AGAINST X-IRRADIATION - ISOPROTERENOL PROTECTS ONLY THOSE CELLS THAT POSSESS BETA-ADRENORECEPTORSстатья Исследовательская статья
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: CHIRKOV YY, KAZAROV AR, MALATSIDZE MA, SOBOLEV AS
- Журнал: Experientia
- Том: 41
- Номер: 11
- Год издания: 1985
- Издательство: Birkh∎user Verlag
- Местоположение издательства: Basel ; Boston, Switzerland
- Первая страница: 1430
- Последняя страница: 1432
- DOI: 10.1007/BF01950019
- Аннотация: In mixed culture of Chinese hamster fibroblatst, clone 431, and transformed murine L fibroblasts, clone B-82, isoproterenol was found to protect only 431 cells against ionizing radiation. It was shown that 431 cells, in contrast to B-82 cells, possessβ-adrenoreceptors, and the radioprotective effect of isoproterenol can be realized only if this agent interacts withβ-adrenoreceptors coupled with the cAMP system. Since malignization often causes the disappearance ofβ-adrenergic and other hormone receptors, the combined culturing and irradiation of the cells studied can be regarded as a model of the growth of malignant cells (B-82) among normal tissue cells (431 cells) under conditions of radiation therapy. A possibility of selective protection against radiation damage of normal tissue cells, with retention of the former radiosensitivity of tumor cells, is discussed.
- Добавил в систему: Соболев Александр Сергеевич