Germ granules in spermatogenesis of Drosophila: Evidences of contribution to the piRNA silencingстатья

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Дата последнего поиска статьи во внешних источниках: 24 января 2020 г.

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[1] Kibanov M. V., Gvozdev V. A., Olenina L. V. Germ granules in spermatogenesis of drosophila: Evidences of contribution to the pirna silencing // Communicative & integrative biology. — 2012. — Vol. 5, no. 2. — P. 130–133. Ribonucleoprotein-containing granules in the cytoplasm of germinal cells are known to be a common attribute of eukaryotic organisms. Germ granules appear to ensure the posttranscriptional regulation of germline mRNAs. Recent studies specify the participation of the germ granules in genome integrity maintenance by mechanisms involving short piRNAs. PIWI clade proteins and associated piRNAs are considered as key participants of the germline-specific piRNA pathway. Proteins of the PIWI clade, Aub and AGO3, concentrated in the germline-specific perinuclear granules called nuage, are involved in silencing of retrotransposons and other selfish repetitive elements in the Drosophila genome. In Drosophila testes, two types of perinuclear nuage granules are found: a large amount of small particles around the nuclei and significantly larger structures, the piNG-bodies. In this mini-review, we analyze the recent published data about structure and functions of Drosophila male germ granules, and especially their involvement in the piRNA silencing pathway. [ DOI ]

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